By Alex Avdeef
Explains easy methods to practice and study the result of the newest physicochemical methods
With this ebook as their advisor, readers have entry to all of the present info had to completely examine and thoroughly confirm a compound's pharmaceutical houses and their results on drug absorption. The publication emphasizes oral absorption, explaining the entire physicochemical equipment used this present day to investigate drug applicants. furthermore, the writer offers professional information to aid readers study the result of their reports so as to choose the main promising drug candidates.
This Second Edition has been completely up-to-date and revised, incorporating all of the most up-to-date study findings, tools, and assets, including:
Descriptions and functions of recent PAMPA versions, drawing on greater than thirty papers released via the author's study group
Two new chapters reading permeability and Caco-2/MDCK and permeability and the blood-brain barrier
Expanded details and techniques to help pKa determination
New examples explaining the therapy of virtually insoluble try compounds
Additional case experiences demonstrating using the newest physicochemical techniques
New, revised, and increased database tables through the book
Well over two hundred drawings support readers higher comprehend tricky suggestions and supply a visible consultant to complicated approaches. additionally, over 800 references function a gateway to the first literature within the box, facilitating additional examine into all of the themes coated within the book.
This Second Edition is usually recommended as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different similar components of analysis. it's also advised as a supplemental textual content for graduate classes in pharmaceutics.
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Extra info for Absorption and Drug Development: Solubility, Permeability, and Charge State
Absorption and Drug Development: Solubility, Permeability, and Charge State by Alex Avdeef